Effect of Triptolide on Content of Adreno-Corticotropic Hormone in Pituitary of Rats
- VernacularTitle:雷公藤甲素对大鼠垂体促肾上腺皮质激素含量的影响
- Author:
Wu ZHANG
;
Jianhua ZHU
;
Wei GUAN
- Publication Type:Journal Article
- Keywords:
Triptolide;
Rat;
ACTH
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Study the effect of long-term triptolide use on the content of the normal rat plasma ACTH.Methods 20 male SD rats were divided into 2 groups randomly,and gavaged for 7 weeks.The control group was 10 with 2%propylene glycol 2ml/kg,bid;the group of Triptolide was 10 with 2% the mixture of propylene glycol and Triptolide 20?g/kg,bid.We used radioimmunoassay to detecet the content of ACTH in rat's plasma and immunocytochemistry to detecet the expression of ACTH in pituitary. Results The content of ACTH in the group of the Triptolide had significant difference as compared with control group.The expression of ACTH in the group of the Triptolide was higher than that of control group. Conclusion These results suggested that one of the possible mechanism of the Triptolide in the HPAA might be exciting pituitary ACTH neurons,thus causing the content of ACTH increasing.
