The Effect of Toll-like Receptor 4(TLR4) on Expression of IRF-3 and IFN-? During Cerebral Ischemia Reperfusion in Hippocampus in Mice
- VernacularTitle:TLR4对脑缺血再灌注小鼠海马IRF-3和IFN-?表达的影响
- Author:
Yanfei CHEN
;
Li ZHOU
;
Yin GAO
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia reperfusion;
TLR4;
TLR4-blocked;
IRF-3;
IFN-?
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Toll-like receptor 4(TLR4)on expression of IRF-3 and IFN-? during the inflammatory reaction induced by cerebral ischemia reperfusion in mice. Methods After blockade of TLR4 by TLR4 antibody,expression of TLR4,IRF-3 and IFN-? at the protein level in hippocampus was examined by Western blot,respectively. Mice were randomly divided into sham group,ischemia reperfusion group and TLR4 blocking group in different time points (1,2,3 and 4 day). Results In the right cortex,the expression of TLR4,IRF-3 and IFN-? of I group was distinctly higher than that of S and T group(P
