Association of Human Epidermal Growth Factor Receptor 2 and Progesterone Receptor Expression in the Estrogen-receptor Negative Breast Cancer Patients
- VernacularTitle:雌激素受体阴性乳腺癌中人表皮生长因子受体2与孕激素受体表达的关系
- Author:
Ning WANG
;
Bin WANG
;
Chunyan XUE
;
Yajie WANG
- Publication Type:Journal Article
- Keywords:
Estrogen receptor;
Progesterone receptor;
Her-2 gene;
Breast neoplasms;
Prognosis
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). Women with triple negative breast cancer experienced more lymph node metastases (71.9%︰58.5%,P=0.034),with the higher percentage of more than 10 lymph nodes metastases(26.0%)as compared with Her-2-overexpressing breast cancer (12.2%,P=0.034). A higher percentage of histological grade 3 was identified in triple-negative (67.7%)than in Her-2-overexpressing breast cancer(42.1%,P0.05). However,significantly poorer 5-year DFS was seen in patients with triple negative phenotype (61.85 months)than with Her-2-overexpressing phenotype (78.69 months,P=0.047). Conclusion Triple-negative breast cancers were more aggressive,and these women had poorer DFS comparing with Her-2-overexpressing ones.
