Effect of Curcumin and TSA on Human Gastric Cancer Cell Line c-myc Expression
- VernacularTitle:姜黄素和TSA对胃癌c-myc表达影响
- Author:
Guangsheng HU
;
Wei SHI
;
Aijun LIAO
- Publication Type:Journal Article
- Keywords:
Curcumin;
TSA;
Gastric cancer;
c-myc;
p53
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the effect of curcumin and TSA on c-myc gene expression in human gastric cancer and to explore the dynamic balance of the histone acetylation / deacetylation in gene expression in gastric cancer and the significance of the regulation. Methods Gastric cancer cell line SGC-7901 and MGC803 were cultured,and then different concentrations of histone acetylase inhibitors curcumin and histone deacetylase inhibitor TSA were added,respectively.mRNA of c-myc expression wasdetected by RT-PCR. Results With increasing of the concentration of curcumin and redcuing of the TSA concentrations c-myc expression was inhibited (P
