Inflammatory stress induces insulin resistance in CD36 knockout mice
- VernacularTitle:炎症应激加重CD36基因敲除小鼠胰岛素抵抗
- Author:
Xian CHEN
;
Qing LIU
;
Han LEI
;
Hong LIU
- Publication Type:Journal Article
- Keywords:
antigens,CD36;
mice,knockout;
inflammation;
insulin resistance
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether the inflammatory stress can increase insulin resistance in the CD36 knockout (KO) mice.Methods After the mice were fed a standard chow for 14 weeks,oral glucose tolerance test,insulin release tests,lipids metabolism,SAA,IL-6,TNF-? and hepatic mRNA and proteins expression of mTOR,S6K,IRS-1,pIRS-1,2 were measured.Results Compared with the wide-type,the CD36 KO mice un-inflamed exhibited insulin resistance,and the insulin resistance index was increased[(3.01?1.24) vs (0.81?0.12),P
