Correlation between ?_2-adrenergic receptor gene Arg16Gly variation and blood-lipid and apolipoprotein ratio mediated by high carbohydrate/low fat diet in healthy young females
- VernacularTitle:?_2肾上腺素受体基因Arg16Gly变异与高糖低脂膳食诱导的健康青年女性血脂及载脂蛋白比值的关联分析
- Author:
Guojin OU
;
Dingzhi FANG
;
Renrong GONG
;
Hui TANG
;
Xin HUANG
;
Zhen ZHANG
;
Juan DU
;
Ronghui LI
- Publication Type:Journal Article
- Keywords:
?2-adrenergic receptor;
gene polymorphism;
high-carbohydrate/low-fat diet;
lipid ratio;
apolipoprotein ratio
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of ?2-adrenergic receptor gene Arg16Gly polymorphism on blood lipid and apolipoprotein ratio and its role in blood lipid and apolipoprotein ratio mediated by high carbohydrate/low fat (HC/LF) diet in healthy young persons.Methods Fifty-six healthy young volunteers had regular diet for 7 d followed by HC/LF diet for 6 d.Twelve-hour fasting venous blood samples were collected on days 1,8 and 14 to measure blood lipid and apolipoprotein (apo) AI and B100 levels,and to calculate ratios of TG/HDL-C,log (TG/HDL-C),TC/HDL-C,LDL-C/HDL-C and apoAI/apoB100.DNA was isolated from genome.Arg16Gly polymorphism was analyzed by PCR-RFLP.Results No significant difference was found in the baseline lipid and apolipoprotein ratio in subjects with AA genotype and G carriers before and after regular or HC/LF diet.The ratios of TG/HDL-C (P=0.017),log (TG/HDL-C) (P=0.031),and apoAI/apoB100 (P=0.006) were significantly higher,while those of TC/HDL-C (P=0.001) and LDL-C/HDL-C (P
