Mining gene expression profi le in def icient cold syndrome with characteristics functional modules
- VernacularTitle:用特征功能模块法挖掘一个虚寒证家系的基因表达谱
- Author:
Liping YANG
;
Rui HUANG
;
Luoxin ZHANG
;
Miqu WANG
;
Wei WU
- Publication Type:Journal Article
- Keywords:
Gene expression profi le;
Gene Ontology;
Functional module;
Feature gene
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the deficient cold syndrome relevant genes and functional modules,based on gene expression profiles and gene functional knowledge to study the molecular mechanism of deficient cold syndrome.Methods:Screening the differential expression genes with Array Tools,and testing the classificational results to the samples.The Gene Ontology Tool was used for annotating characteristics functional gene,selecting functional modules enriched with differentially expressed genes;and then identifing the feature modules and analyzing their association with the deficient cold syndrome.Results:The accuracy rate of classification samples was 93% with 25 different gene,the accuracy rate was 87%-100% with 11 functional modules.Conclusion:These features function modules had some relevance to the occurrence of deficient cold syndrome.It was more favorable interpretation of the disease by studying functional modules based on gene expression profiles.
