Effect and potential mechanism of replenishing the kidney and eliminating phlegm therapy on CaMKⅡ-? activities of AD rat model
- VernacularTitle:补肾化痰方药对阿尔茨海默病模型大鼠脑组织钙/钙调素依赖的蛋白激酶Ⅱ-?活性的影响
- Author:
Hui HU
;
Ping WANG
;
Mingwang KONG
;
Fengmin DING
- Publication Type:Journal Article
- Keywords:
Replenishing the kidney and eliminating phlegm therapy;
Alzheimer;
Calciurn/calmodulin-dependent protein kinaseII-?(CaMKII-?);
Tau protein
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of replenishing the kidney and eliminating phlegm therapy on calciumlcalmodulin-dependent protein kinase Ⅱ(CaMKⅡ-?) activities of AD rat model,and explore the potential mechanism.Methods:AD model was established by injection of ibotenic acid(IBO) and 25-35 ?-amyloid peptide(A?25-35) into basal nucleus of Meynert.After injecting for two weeks,Bushen Huatan Decoction was administered by oral gavage of high,middle and low dosages.Huperzine A-Zhulin Antun tablets served as control drug.Normal group,model group and blank group were administered with isovolumetric saline water.After treating for four weeks,hybridization in situ was used to observe the change of CaMK Ⅱ in hippocamp.Results:The expression of CaMKⅡ-? in model group was more than that in normal group(P
