Influence in Shumai Capsule on Ang Ⅱinduced vascular smooth muscle dell proliferation and level of NO,SOD,MDA
- VernacularTitle:舒脉胶囊对血管紧张素Ⅱ诱导的血管平滑肌细胞增生及NO、SOD、MDA的影响
- Author:
Jianxun DONG
;
Sheng YU
;
Guanglin LU
;
Yu HAO
;
Meiji ZHANG
;
Chaojun ZHU
- Publication Type:Journal Article
- Keywords:
Shumai Capsule;
Angiotensin Ⅱ;
Vascular smooth muscle cell;
Oxide;
Superoxide dismutase;
Malondialdehyde
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the impact of the medicated serum of Shumai Capsule and its decomposing on vascular smooth muscle cells(VSMC) proliferation induced by angiotensinⅡ(AngⅡ) and level of NO,SOD,MDA in cell culture supernatant.Methods:Tissue explant method was used for cultivating vascular smooth muscle cells,serum pharmacology was used,AngⅡ10-7mol/L as a stimulating factor,medicared serum divided into Shumai Capsule group,Huoxue Huayu decomposing group(group 1) and Bupi Yishen decomposing group(group 2),MTT colorimetric was used to test OD values,biochemical detection kit was used to test NO,SOD,MDA levels.Results:The OD value of Shumai Capsule and group1 had significant difference from AngⅡ group and group2(P
