Study of Fanggan Decoction,s death prevention on mouse and inhibition effects on Influenza A virus
- VernacularTitle:防感煎剂对甲型H1N1流感病毒感染小鼠死亡干预和抑制病毒的实验研究
- Author:
Kang SONG
;
Xianfang LUO
;
Yuguan WANG
;
Yongliang XIA
;
Yu CAO
- Publication Type:Journal Article
- Keywords:
H1N1 influenza virus;
Fanggan Decoction;
Antivirus
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the Fanggan Decoction,s death prevention on mouse and inhibition effects on Influenza A virus in vivo.Methods:After setting up the model of mouse infected with Influenza A virus(H1N1),we observed the death prevention with Fanggan Decoction,done hemagglutination test and detected the dynamic contents of virus with Real-Time Fluorescence Quantitative RT-PCR.Results:Fanggan Decoction can prevent the death of infected mouse and delay the survival time.The death rate was 66.67%,33.33% and 25% respectively in low,middle and high dose of Fanggan Decoction groups and the average survival time was respectively 8.75 days,11.41 days and 12.33 days.Virus contents reached peak on the 5th day,while compared with the model group,virus contents were lower in each Fanggan Decoction groups,especial in the middle and high dose groups.Conclusion:Fanggan Decoction had good effect in inhibiting Influenza A virus,and can prevent the death of infected mouse,delay the survival time,while get better antivirus dose-effect relationship at double dose.
