Effect of Qingxin Yangshen Chinese herbs on ?-adrenoceptor in cardiocytes of stress rats
- VernacularTitle:清心养神方药对束缚应激大鼠心肌细胞肾上腺素?受体的影响
- Author:
Yanling XIAO
;
Shuran MA
;
Qiang LIU
- Publication Type:Journal Article
- Keywords:
Qingxin Yangshen Chinese herbs;
Stress;
Myocardium cells of rats;
?-adrenoceptor
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of Qingxin Yangshen Chinese herbs on ?-adrenoceptor in cardiocytes of stress rats.Methods:Adopting the method of radoligand binding,the affinity of ?-adrenoceptor of experimental myocardium cells and density were analyzed.Meanwhile,RT-PCR was used to test mRNA of ?-adrenoceptor of myocardium cells.To observe the effect of Qingxin Yangshen Fang on ?-adrenoceptor of myocardium cells of stress rats,and the Zhusha Anshen Pills and Propranololas the control groups.Results:All the three groups above can increase the affinity of ?-adrenoceptor of experimental myocardium cells,promote its sensitivity and notably inhibit the decrease of density of receptors and control down-regulation of expression of ?1-ARmRNA induced by stress,and regulate up the expression of ?2-ARmRNA.Conclusion:The Chinese herbs of Qingxin Yangshen had the effect of acceptor inhibiting and can regulate the changes of ?-adrenoceptor of myocardium cells induced by stress.
