A Case of Hepatoid Carcinoma of the Pancreas.
- Author:
Hyun Jong OH
1
;
Dae Young CHEUNG
;
Tae Ho KIM
;
Soon Sub KIM
;
Myoung Seok KIM
;
Jin Il KIM
;
Soo Heon PARK
;
Joon Yeol HAN
;
Nam Ik HAN
;
Jae Kwang KIM
;
Young Sok LEE
;
Eung Kook KIM
;
Eun Sun JUNG
Author Information
1. Departments of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. jyhan@catholic.ac.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Hepatoid carcinoma;
Pancreas
- MeSH:
Adult;
Carcinoma, Hepatocellular/pathology;
Humans;
Male;
Pancreatic Neoplasms/*diagnosis/pathology
- From:The Korean Journal of Gastroenterology
2006;47(5):389-393
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hepatoid carcinoma is a primary extrahepatic neoplasm exhibiting features of hepatocellular carcinoma (HCC) in terms of morphology, immunohistochemistry, and behavior. In many cases, tumor cytoplasm is positive for alpha- fetoprotein (alpha-FP) with elevated serum alpha-FP level. Because not all hepatoid carcinomas are associated with alpha- FP overproduction, diagnosis should be made essentially by histological features of the tumor. We present a case of hepatoid carcinoma of the pancreas in a 21-year-old male patient. Abdominal computed tomography and magnetic resonance imaging revealed an inhomogeneously enhanced pancreatic head mass. Serum alpha-FP level was markedly elevated. He underwent pylorus-preserving Whipple's operation. The tumor showed hepatoid and neuroendocrine components simultaneously. The histopathological diagnosis was hepatoid carcinoma associated with neuroendocrine tumor of the pancreas. Seven months after the surgery, the patient is healthy without evidence of recurrence. To date, only 7 cases of hepatoid carcinoma of the pancreas have been reported in the literature, and this is the first case report in Korea.
