Clinical significance of cytogenetics in myelodysplastic syndrome
- VernacularTitle:细胞遗传学诊断骨髓增生异常综合征临床意义
- Author:
Yongquan XUE
- Publication Type:Journal Article
- Keywords:
myelodysplastic syndrome;
cytogenetics;
fluorencence in situ hybridization;
karyotype
- From:
Chinese Journal of Practical Internal Medicine
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper introduces cytogenetics in myelodysplastic syndrnme(MDS)in three parts:(1)the frequency rate and types of clonal chromosomal abnormalities in MDS;(2)the value of cytogenetics in the diagnosis,classification,prognosis and treatment of MDS;(3)evaluation of the cytogenetics methods in MDS.Every patient suspected of MDS should receive chromosome examination.About 40%～70% of primary MDS patients and 95% of therapy-related MDS(t-MDS) patients have a clonal chromosomal abnormalities.The frequency rate is related to not only the disease's stages,but also the methods of examination.The types of chromosomal aberrations show huge heterogeneity including various numerical and structural abnormalities,the most common of which are numerical abnormalities and deletion.International score system for evaluating prognosis in MDS has been used worldwide.It dividing the prognosis of MDS into three deferent kinds:high risk,low risk and intermediate risk.The conventional karyotypic analysis (CC) is the most useful method.Fluorencence in situ hybridization (FISH) is an important supplement to CC.CC in combination with FISH will be likely to make an accurate chromosomal analysis for most MDS patients.
