Establishment of rabbit model of obstructive sleep apnea syndrome and its pathophysiological changes
- VernacularTitle:低压缺氧建立阻塞性睡眠呼吸暂停综合征兔模型的研究
- Author:
Ni ZHANG
;
Xi LIU
;
Gang LIU
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
sleep apnea;
obstructive;
animal model;
rabbits
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the establishment of rabbit model of obstructive sleep apnea syndrome(OSAS) through hypobaric hypoxia and their changes in pathophysiology.Methods Twelve adult rabbits were randomly assigned to 2 groups,control group and experimental group.The rabbits of experimental group were placed in hypobaric hypoxia cabin,in which the altitude was 5 000 m,10 h daily,for 4 weeks.The rabbits of control group were raised normally.The airway were scanned by CT,arterial blood gas was analyzed and respiratory airflow was monitored.The rabbits were sacrificed after the experiment,and pharyngeal tissue and genioglossus were harvested for pathological examination.Results In hyoid bone plane of upper airway,the pharyngeal of experimental group showed significant thickened(P
