Experimental study on therapeutic effects of dihydromyricetin on hepatic fibrosis in murine schistosomiasis
- VernacularTitle:二氢杨梅素治疗血吸虫病肝纤维化的实验研究
- Author:
Huilong FANG
;
Junjie WANG
;
Meizi CHEN
;
Lei JIA
;
Chunwei LI
- Publication Type:Journal Article
- Keywords:
Dihydromyricetin;
Schistosomiasis;
Hepatic fibrosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the therapeutic effect of dihydromyricetin on experimental schistosoma japonicum hepatic fibrosis in mice. METHODS:60 mice infected with schistosma japonicum cercariae percutanoeusly were divided into 3 groups:model group,praziquantel group, praziquantel plus dihydromyricetin group and other 20 normal mice were used as control group.After treatment with medicine for 8 weeks,the liver was removed and weighed.The contents of ALT and AST in serum were assayed using the corresponding kits.Moreover, the degree of hepatic fibrosis was observed Via HE and was scored.The expression of collagenⅠprotein and collagenⅢprotein were measured by immunohistochernical method.RESULTS: The mice that infected with schistosoma japonicum, had a featuring increment in liver weights,serum ALT,AST contents,the expression of collagenⅠprotein,collagenⅢprotein (P
