Progress of the study on relations between renin angiotensin system and vascular remodeling of hypertension
- VernacularTitle:肾素血管紧张素系统与高血压血管重构关系的研究进展
- Author:
Yongjie YUAN
;
Ancai WANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Vascular remodeling;
Renin-angiotensin system
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Hypertensive vascular remodeling has always been a hot program in clinic and basic research.Renin-angiotensin system is an importent regulatory mechanism of human physiological function,which plays a fundamental role in vascular remodel- ing.RAS consists of two axes, ACE-AngII-AT_1 receptor axis and ACE2-Ang(1- 7)-Mas receptor axis.The former affects vasoconstriction and promotes vascular re-modeling through its key member,AngII;the latter offsets the effect of the mentioned AngII with the help of seven-peptide Ang-(1-7).A deep knowledge of the relation between RAS and vascular remodeling would provide more remedies for reducing cardiovascular risk.
