Progress in sleep-wake regulation of dopamine D_2 receptor
- VernacularTitle:多巴胺D_2受体调控睡眠-觉醒研究进展
- Author:
Qi XU
;
Weimin QU
;
Zhili HUANG
- Publication Type:Journal Article
- Keywords:
Dopamine;
D_2 receptor;
Knockout mice;
Sleep;
Wake
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Dopamine(DA) modulates diverse wake-related behaviors including movement,reward, and cognition.Dopaminergic neurons are located in the substantia nigra pars compacta and ventral tegmental area.There are five distinct DA receptors(R):D_1R,D_2R(D_(2S)R and D_(2L)R), D_3R,D_4R and D_5R in the central nervous system, in which D_1R and D_2R are majorly expressed. The affinity of D_2R for endogenous DA is significantly higher than that of D_1R.Re- cently,studies by pharmacological and gene knock-out animals revealed that dopamine D_2R is essential inmaintaining wakefulness.Here,we review the progress on roles of D_2R in sleep-wake regulation.
