Thiazolidinediones combined with metformin in treatment of polycystic ovary syndrome:a systematic review
- VernacularTitle:噻唑烷二酮类药物和二甲双胍联合治疗多囊卵巢综合征的系统评价
- Author:
Tingting HAN
;
Jun ZHENG
;
Yaomin HU
- Publication Type:Journal Article
- Keywords:
thiazolidinediones;
metformin;
polycystic ovary syndrome;
systematic review
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and safety of thiazolidinediones combined with metformin in treatment of polycystic ovary syndrome.Methods Electronic database searching was performed on Medline,Cochrane Library,EMbase,EBSCO,ScienceDirect,OVID,Springer LINK,Wiley,Chinese biology and medicine(CBM),China National Knowledge Infrastructure(CNKI),and Chongqing VIP Database;meanwhile,unpubished literature,conference papers and dissertations were also searched manually.The data included those from the establishment to November 2009.Randomized or clinical controlled trials concerning the thiazolidinediones and metformin combination therapy for PCOS were selected and assessed for the methodological quality,and Meta-analysis was performed using statistical software Revman 5.0.Results Five randomized controlled trials met the inclusion criteria and were included.Compared to metformin group,thiazolidinediones combined with metformin significantly improved insulin resistance(P
