Dual-role regulations of canonical Wnt/?-catenin signaling pathway
- VernacularTitle:经典Wnt/?-catenin信号通路中的双向调控
- Author:
Yang LIU
;
Chenguang ZHANG
;
Chunyan ZHOU
- Publication Type:Journal Article
- Keywords:
Wnt proteins;
Signal transduction;
Intercellular signaling peptides and proteins
- From:
Journal of Peking University(Health Sciences)
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,Wnt/?-catenin signaling has been identified as a key player in embryogenesis and human diseases.Canonical Wnt signaling pathway is controlled by a variety of classic molecules like Wnt,?-catenin,Axin,APC,GSK-3? and CK1,which interact and coordinate to regulate the expressions of cell signaling molecules.The latest evidences suggest that some components of the Wnt/?-catenin signaling,like APC,GSK-3?,CK1,Dkk2 and WISE,play dual roles different from what they have been thought previously.Here we reviewed some recent discoveries on the canonical Wnt/?-catenin signaling pathway to provide some new ideas and principles for signaling transduction studies.
