Treatment Effect of Zuogui Pill on Immune Premature Ovarian Failure Rats
- VernacularTitle:左归丸对免疫性卵巢早衰小鼠的治疗作用
- Author:
Hongmei LI
;
Zhiyong ZHONG
;
Zhulin MIAO
;
Xiangcai WEI
;
Qiang FAN
- Publication Type:Journal Article
- Keywords:
Zuogui pill;
Premature ovarian failure;
Sexual cycle;
Cells apoptosis
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the treatment effect of Zuogui pill (ZGP) on immune premature ovarian failure rats.Methods Female mice model of POF was established by multiple sites subcutaneous injection of zona pellucida 3,and treated with different dosage ZGP (low, middle and high),with prednisone and diaethylstilbestrol as positive control. We detecteed apoptosis rate of granulosa and oocyte of murine ovaries by tunel method and observd the change of sexual cycle and weight. Results Compared with the control group,the weight of model group rat in the third to eighth weeks was significant difference (P
