Effects of Naloxone on Myocardial Ischemia-reperfusion Injury in Rats
- VernacularTitle:纳洛酮对大鼠心肌缺血再灌注损伤的影响
- Author:
Zhibing GAO
;
Yun WANG
;
Jiwei GU
- Publication Type:Journal Article
- Keywords:
Noaloxone;
Ischemia-reperfusion injury;
Rat
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of naloxone(Naloxone,NAL) on myocardial ischemia-reperfusion injury in rats,and to explore its mechanism.Methods 36 male SD rats were randomly divided into blank control group (Con group),ischemia-reperfusion group (I/R group),ischemic preconditioning group (IPC group) and naloxone pretreatment group (Nal+I/R group).Changes of cardiac function,myocardial infarct size and occurrence of arrhythmias after ischemia-reperfusion in each roup were observed.Changes of myocardium under light microscope ultrastructural in each group were also observed.Apoptosis situation in each group was detected by TUNEL assay.Results Compared with th IR group,IPC group and Nal+I/R group showed significantly improvement in cardiac function after ischemia-reperfusion (P
