Relation Between Level of CA125 and Heart Function as well as Myocardial Remodeling in Patients with Congestive Heart Failure
- VernacularTitle:慢性心力衰竭患者CA125表达与心肌重构及心功能相关性分析
- Author:
Hongyan DUAN
;
Lixia WANG
;
Jianmin LU
;
Liuyi WANG
;
Ping LUO
;
Haohui ZHU
- Publication Type:Journal Article
- Keywords:
CA125;
Congestive heart failare;
NT-pro BNP;
TNF-2;
LVMI;
LVAVI;
LVEF
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relation between the level of serum carbohydrate antigen-125 (CA125) and heart function as well as the myocardial remodeling in patients with congestive heart failure(CHF). Methods 79 patients with CHF were divided into three groups based on the standard of New York Heart Association Classification. 25 healthy persons were served as control group. Level of CA125 was measured by MEIA. NT-proBNP was detected by Roche Cardiac Reading instrument. TNF-? was measured by radioimmunoassay. Left ventricular mass index (LVMI),left atrial volume index (LAVI) and left ventricular ejection fraction (LVEF) were detected by echocardiography. The levels of CA125,NT-proBNP,TNF-?,LVMI,LAVI and LVEF in different groups were compared.The relationship between CA125 and NT- proBNP,TNF-?,LVMI,LAVI and LVEF was evaluate.Results Levels of CA125,NT-proBNP,TNF-?,LVMI and LAVI in patients with CHF were much higher than those without CHF. The LVEF was much lower in NYHA Ⅲ and NYHA Ⅳ group than that in without CHF and NYHAⅠgroup. Conclusion CA125 was positively associated with the NT-proBNP,TNF-? and LVMI.
