A Control Study of N-acetylcysteine Therapy for Chronic Obstructive Pulmonary Disease
- VernacularTitle:N-乙酰半胱氨酸治疗慢性阻塞性肺疾病的对照研究
- Author:
Yingxia FU
;
Xizhu WANG
;
Yajun YUAN
;
Hui YIN
;
Lina WANG
- Publication Type:Journal Article
- Keywords:
COPD;
N-acetylcysteine;
hs-CRP;
TNF-?;
Airway remodeling;
Inflammatory factor
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective NAC therapy was used to observe the effect of TNF-?,hs-CRP,PaO2,PaCO2and lung function in patients with COPD,so as to evaluate the therapeutic effect. Methods 65 patients with COPD were recruited and the patients were randomly divided into 2 treatment groups:control group (n=31) and experimental group (n=34). Patients in the two groups received the conventional treatment of COPD in unchanged dosage for the duration of the study except stopping using antibotic drug after infection was resolved. NAC tablets were taken orally at a dose of 600mg once a day in experimental group. After 8 weeks treatment,we appraised lung function and the plasma level of TNF-?,hs-CRP,PaO2 and PaCO2. Results Compared with normal controls,the plasma levels of TNF-? and hs-CRP increased significantly. The higher level of those ,the higher lung function class was in 65 COPD patients,and there was significant effect(P
