Methylation of TSHR Gene Promoter in Papillary Thyroid Carcinoma
- VernacularTitle:甲状腺乳头状癌组织中TSHR基因启动子甲基化研究
- Author:
Jiandong TANG
;
Xialian LI
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinomas (PTC);
Thyroid stimulating hormone receptor gene (TSHR gene);
Methylation-specific PCR(MSP)
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the characteristics of promoter methylation of thyroid stimulating hormone receptor(TSHR) gene in papillary thyroid Carcinomas(PTC) and the clinical manifestation of PTC. Methods The methylation status of TSHR gene was detected by methylation specific PCR technique(MSP).Results (1) The methylation rate of TSHR gene in PTC tissues was 64.7%(22/34),while the methylation rate of TSHR gene in adjacent thyroid tissues(ATT) was 26.5%(9/34),and the rate of methylation of TSHR promoter in PTC was significantly higher than of ATT(P
