Effects of Ulinstatin on Oxygenation and Gastric Intramucosal pH in Dogs with Sepsis
- VernacularTitle:乌司他丁对脓毒症犬氧代谢和胃黏膜pH值的影响
- Author:
Jianping YIN
;
Xiongjian XIAO
;
Jiandong LIN
- Publication Type:Journal Article
- Keywords:
Sepsis;
Ulinastatin;
Oxygenation;
pHi
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Ulinstatin(UTI) on oxygenation and gastric intramucosal pH in dogs with sepsis. Methods Sepsis was induced by intravenous infusion of lipopolysaccharide of E.coli.055:B5 to dogs,and the twenty dogs were divided into control group and ulinastatin group.Ulinastatin was administered in the ulinastatin group.The oxygen delivery(DO2),oxygen consumption(VO2), oxygen extraction(O2ER), plasma lactate levels and gastric intramucosal pH(pHi) were monitored. Results In early sepsis dogs,DO2,VO2,O2ER and plasma lactate levels increased significantly. Gastric intramucosal pH(pHi) decreased significantly. After the treatment with ulinastatin,DO2,VO2,O2ER and plasma lactate levels decreasd(P
