Inhibitive effect of Eqi-anticarcinogen Prescription on associated gene protein in process of rat hepatocarcinoma induced by diethylnitrosamine
- VernacularTitle:莪芪抗瘤方对二乙基亚硝胺诱导大鼠肝癌过程中相关蛋白的影响
- Author:
Xiuyun SHEN
;
Tong WU
;
Yanli ZHAO
- Publication Type:Journal Article
- Keywords:
Hepatocarcinoma;
Proliferating cell nuclear antigen(PCNA);
Anti-Oncogene proteins;
Immunohistochemistry
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the influence of the Ewi-anticarcinogen Prescription on associated gene protein in process of rat hepatocarcinoma induced by diethylnitrosamine (DEN). Methods: Rats hepatocarcinoma model was induced by DEN, while the Eqi-anticarcinogen Prescription was used during the stage. At the end of 12th week and 16th week, the influence of the Eqi-anticarcinogen Prescription on positive expression of PCNA and p53 protein were examined by immuneohistochemical method. Results: The positive expression of p53 protein was occurred in precancerous hyperp lastic nodules; The Eqi-anticarcinogen Prescription can significantly inhibit the overexpression of p53 (P
