The effect and the mechanism of bortezomib on bone disease in patients with multiple myeloma
- VernacularTitle:硼替佐米对多发性骨髓瘤骨病的作用及其机制探讨
- Author:
Juan LI
;
Yan DING
;
Lijin ZENG
;
Jingli GU
- Publication Type:Journal Article
- Keywords:
multiple myeloma;
bortezomib;
skeletal related events;
bone turnover marker
- From:
Chinese Journal of Practical Internal Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether bortezomib combined with dexamethasone can relieve bone pain of patients with multiple myeloma and to see whether bortezomib have effect on bone metabolism through determining the concentration of bone turnover marks.Methods 59 cases of patients with multiple myeloma treated with BD and 38 cases of patients treated with VADM were observed before and after chemotherapy to compare the alleviation of bone pain,the improvement of the ability to move and the occurrence of skeletal related events between the two groups.The plasma from 25 patients were collected before and after chemotherapy when they were in hospital each time and the concentrations of TRACP-5b,BALP and DKK1 in plasma were determined by ELISA.Results BD group was better than VADM group in the rate of alleviation of bone pain,the improvement of the ability to move and the incidence of skeletal related events(75.7% vs 50%,64.9% vs 20.8% and 13.8% vs 57.8%,all P
