Expression and clinical significance of heat shock protein 60 in cervical carcinoma
- VernacularTitle:热休克蛋白60在子宫颈癌组织中的表达及其临床意义
- Author:
Jun FENG
;
Lijuan WANG
;
Xiaobing HAN
;
Xingye WANG
;
Wenli GOU
- Publication Type:Journal Article
- Keywords:
cervical cancer;
heat shock protein 60;
reverse transcription polymerase chain reaction
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of heat shock protein (HSP) 60 and analyze the significance in cervical carcinoma. Methods The cervical tissue samples of 57 cases of cervical cancer and 57 normal cervical tissues were collected. The expression of HSP60 were detected by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR). The protein expressions of HSP60 were determined by Western blot analysis. To observe the relationship between HSP60 expression and the occurrence and development of cervical cancer. Results HSP60 mRNA expression in normal cervical tissue was significantly lesser than that in cervical cancer tissue (t=2.65, P0.05). The levels of HSP60 protein expression in normal cervical tissue was significantly lower than the expression in cervical cancer tissue (t=3.132, P
