Effects of panax notoginsenosides on bone histomorphometry in rats with hyperlipidemia-induced osteoporosis
- VernacularTitle:三七总苷对高脂血症性骨质疏松大鼠骨代谢的影响
- Author:
Qingqing NA
;
Hua XIE
- Publication Type:Journal Article
- Keywords:
Panax notoginsenosides;
Osteoporosis;
Hyperlipidemia;
Bone histomorphometry
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the effects of panax notoginsenosides(PNS)on bone histomorphometry in rats with hyperlipidemia-induced osteoporosis.METHODS:Thirty 3-month-old Sprague-Dawley rats were randomly divided into three groups with 10 per group as follows.Control group was intragastrically given distilled water at the dose of 5 mL?kg-1?d-1 for 20 weeks;Model group was intragastrically given lipid emulsion at the dose of 5 mL?kg-1?d-1 for 20 weeks;PNS preventing group was intragastrically given lipid emulsion at the dose of 5 mL?kg-1?d-1 in the morning and PNS at the dose of 5 mL?kg-1?d-1 at afternoon for 20 weeks.At the end of the experiment,the right longitudinal proximal tibial metaphyseal parameters of rats were performed undecalcifiedly and used for bone histomorphometry analysis.And the blood serum contents of FFA,TG,TC,HDL-C and LDL-C were measured by biochemical analysis.RESULTS:Compared with model group,the blood serum contents of FFA,TC and LDL-C were decreased and HDL-C was increased significantly(P
