Research of effect of Compound Rehmannia on Transgenic Mice with SAM-P/8 Alzheimer′s Disease
- VernacularTitle:复方地黄对转基因早老性痴呆小鼠SAM-P/8的作用研究
- Author:
Kuiyuan HOU
;
Lihui SUN
;
Pengpeng CAI
;
Donghong WANG
;
Guohua JIANG
- Publication Type:Journal Article
- Keywords:
Compound rehmannia;
Learning and memory ability;
SOD;
Na+-K+-ATP enzyme;
Apoptosis cells
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of compound rehmannia on SOD and ATP enzyme in the brain of SAM-P/8 dementia mice and the change of apoptosis neuron cells.Methods SAM-P/8 mice were divided randomly into three groups:experimental group,treatment group and model group.Mice in experimental group were lavaged by compound rehmannia(2ml/day,individual).Mice in treatment group were lavaged by donepezil hydrochloride(400mg/kg,individual),and mice in normal group and model contrast group were lavaged by equal sodium chloride.After 3 weeks,we observed mice′s behavior in every group and investigated the changes of SOD,Na+-K+-ATP enzyme by immunohistochemistry and investigated the changes of apoptosis cells peak by FCM.Results Compound rehmannia could improve learning and memory ability of the SAM-P/8 mice,strengthen SOD,Na+-K+-ATP activity and reduce apoptosis neurons in brain.Conclusion Compound rehmannia can significantly improve the Alzheimer's mice learning and memory ability,strengthen the energy of brain cells,and increase resistance to free radical antioxidant capacity,reduce the neuron apoptosis and has a good relatively protection and care to SAM-P/8 mice brain neurons.
