Expression of Plasma Soluble HLA-G and Factors Involving Influencing its Expression Levels in Patients with Systemic Lupus Erythematosus
- VernacularTitle:系统性红斑狼疮患者血浆sHLA-G表达及其影响因素分析
- Author:
Fengxia WU
;
Lijun WU
;
Xiongyan LUO
;
Minghui YANG
;
Ningtao LIU
;
Banjiang KUER
;
Chuangmei XIE
;
Xiaoyun SONG
;
Zhong TANG
;
Guoyuan ZHANG
;
Jingguo ZHOU
;
Yan ZHAO
;
Xiaofeng ZENG
;
Guohua YUAN
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus;
Systemic;
Human leukocyte antigen G;
Soluble HLA-G;
Polymorphism
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).However,the patients with increased levels of sHLA-G had higher incidence of central nervous system involvement(P=0.007) and more severe disease activity(P=0.027) in comparison with patients with normal plasma sHLA-G levels.Finally,the expression of plasma sHLA-G was not influenced by the treatment with glucocorticoids,immunosuppressive agents or antimalarials.Conclusion The increased production of sHLA-G indicates that sHLA-G may play an important role in the pathogenesis of SLE.The expression of sHLA-G may be associated with disease activity and severity of lupus patients,but be independence of HLA-G 14bp ins/del polymorphism and drug treatment.
