Expression of E-cadherin and ?/? Catenins and their Relationship with the Invasiveness of Pituitary Adenoma
- VernacularTitle:上皮钙黏蛋白及?/?连环蛋白的表达与垂体腺瘤侵袭性的关系
- Author:
Kun LIU
;
Yugang JIANG
- Publication Type:Journal Article
- Keywords:
E-cadherin;
Catenins;
Pituitary adenoma;
Invasive
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression of E-cadherin catenin complex(CCC) and the invasiveness of pituitary adenoma.Methods The expession of E-cadherin catenin complex was determined by immunohistochemistry in 45 cases of human pituitary adenomas by random sampling,including invasive adenoma 27 cases,noninvasive adenoma 18 cases.The relativity of their expression with hormone-producing,pituitary apoplexy and necrosis or cystoid change,tumor diameter was analyzed.Results The invasive group had a significantly lower expression of E-cad and ?-cat than that of noninvasive group(?2=8.551,P0.05).Moreover,the expression of E-cad was significantly lower in endocrine inactive group than that in endocrine active group(?2 =5.020,P
