Clinical Study of Acute Promyelocytic Leukemia Treated by the Combination of All-trans Retinoic Acid with Arsenic Trioxide
- VernacularTitle:全反式维A酸联合三氧化二砷治疗急性早幼粒细胞性白血病的临床研究
- Author:
Pengfei WU
;
Rong KONG
;
Hongchun QIU
;
Yong WANG
- Publication Type:Journal Article
- Keywords:
Leukemia;
Promyelocytic;
Acute;
Retinoic acid;
Arsenicals
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic efficacy of all-trans retinoic acid(ATRA) combined with arsenic trioxide(As2O3) on acute promyelocytic leukemia(APL).Methods 9 patients of APL underwent ATRA with As2O3 therapy.The patients in combination group were treated with ATRA 25mg/(m2?d) and As2O3 10mg intravenously for 3 to 4 hours per day until complete remission(CR) or for 50 days.According to the white blood cell(WBC) counts,anthracycline and cytosine arabinoside(Ara-C) were added on third day.Results 6 newly-diagnosed and 2 relapse patients of the combination group were CR after first treat.The medium time to CR was 30.12?4.89 days.Conclusion ATRA + As2O3 with anthracycline regiment is superior to either regiment given alone to patients with APL.It is an efficient therapeutic approach to APL patients using a combination of ATRA with As2O3.
