Experimental study on effect of Simiao Yongan Decoction on NF-?B and associated inflammatory factor
- VernacularTitle:四妙勇安汤调控核因子-?B活性及抑制相关炎症因子的实验研究
- Author:
Junping ZHANG
;
Ming LI
;
Liangjun LI
;
Li PENG
;
Yingzhi XU
;
Guangyin ZHNG
;
Cui YANG
;
Yanan ZHOU
- Publication Type:Journal Article
- Keywords:
Simiao Yongan Decoction;
Atherosclerosis;
Nuclear factor-?B
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe whether the Simiao Yongan Decoction regulate the nuclear factor-?B(NF-?B) expression and related factors in atherosclerosis(AS)rabbit model,thus restrain the occurrence of atherosclerosis and plaque formation.Methods:56 male Japanese rabbits were randomly divided into normal group,model group,Simvastatin group and Simiao Yongan Decoction group,in addition to the normal group,other groups were established aortic atherosclerotic plaque model.From the1st day of experiment,the corresponding drug intervention began,10 weeks later,the rabbits were killed over the weekend after the anesthesia line access aortic NF-?B immunohistochemical staining,and the experimental dynamic 0,3,6,10 weeks in serum TNF-?,IL-1 and MCP-1 content.Results:The expression of NF-?B p65 subunit in model group was rich,and compared with it,the expression of NF-?B p65 subunit in treatment groups decreased,and the Simiao Yongan Decoction can obviously inhibit the expression of NF-?B p65 subunit.In model group,the expressions of IL-1,TNF-?and MCP-1 in serum increased significantly at different time points(P
