Effect of Anlv Capsule on sodium ion channels in ventricular myocytes of guinea pig
- VernacularTitle:安律胶囊对豚鼠心室肌细胞钠离子通道的影响
- Author:
Huimei XU
;
Xiaogang JIANG
;
Wenjie ZHANG
;
Yan LI
;
Jiayi REN
- Publication Type:Journal Article
- Keywords:
The ANLV capsules;
ventricular myocytes;
sodium current;
The whole-cell patch-clamp recording technique;
Premature beats
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of Aalv Capsule on sodium current in guinea pig ventricular myocytes(INa)for exploring the mechanism of its anti-premature beats.Methods:Whole-cell patch-clamp recording technique was used to record the Aalv Capsule for a single cell of sodium currents in guinea pig ventricular myocytes.Results:There was dose-dependent of Aalv Capsule in block of sodium currents and had a certain amount of use-dependent and time-dependent.Conclusion:The role of Aalv Capsule in blocking sodium current block was one of the mechanisms of its in bearing premature.
