Mononuclear cells count can reliably predict hematopoietic reconstitution following allogeneic peripheral blood stem cell transplantation
- VernacularTitle:单个核细胞计数对异基因外周血干细胞移植后造血重建的预测研究
- Author:
Liang WANG
;
Kanger ZHU
;
Tao ZHANG
;
Jie CHEN
;
Jun ZHONG
- Publication Type:Journal Article
- Keywords:
peripheral blood stem cell transplantation;
allogeneic;
mononuclear cell,CD34+ cell;
hematopoietic reconstitution
- From:
Chinese Journal of Practical Internal Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).There was a positive correlation between the tempo of the engraftment and the progressive increase of the doses of MNC in the range of (3～5.99)?108/kg,but which was not found in the range of 6?108/kg.Conclusion These results indicate that MNC taken as an index for the measurement of the hematopoietic stem cell/progenitor content can reliably predict hematopoietic reconstitution after both HLA-matched and-mismatched sibling donor peripheral blood stem cell transplantation,with the rate and tempo of engraftment comparable with that in CD34+ cell group,and however,the target dose was reached with one apheresis in all 83 donors in MNC group(100%),as compared with 14 donors in CD34+ cell group(37.84%),suggesting that MNC may replace CD34+ cell as an independent index for the assessment of the stem cell/progenitor content in clinical practice.
