EFFECT OF TEA POLYSACCHARIDE ON GLUCOSE METABOLISM,HISTOMORPHOLOGY AND PANCREATIC ISLET BETA-CELL ULTRASTRUCTURE IN DIABETIC MICE
- VernacularTitle:茶多糖对糖尿病小鼠糖代谢、组织形态学及胰岛?细胞超微结构的影响
- Author:
Jianguo CHEN
;
Weiqi LAI
;
Yuexian JIANG
;
Song MEI
;
Dongying LIU
;
Ying FU
- Publication Type:Journal Article
- Keywords:
tea polysaccharides;
diabetes;
glucose metabolism;
pancreatic islet ?-cell
- From:
Acta Nutrimenta Sinica
1956;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study tea polysaccharides(TP) on glucose metabolism,histopathology,and pancreatic islet ?-cell ultrastructure in diabetic mice.Method The alloxan diabetic mice were randomly divided into 4 groups,and orally given distilled water,TP 0.25,0.50,1.00 g/(kg bw?d).for 5 w,and weighed once every week.In experiment 2 and 4 w,the fasting blood glucose was tested once.The glucose tolerance test was conducted at the end of experiments.Blood serum insulin and liver glycogen were measured.The protein content,hexokinase(HK) and pyruvate kinase(PK) activity of 10% liver homogenate were measured.The histopathology of liver,pancreas,kidney and spleen tissue and the ultra structure of pancreas were observed.Results TP could significantly alleviate the symptoms of diabetic mice.The fasting blood glucose values in three TP groups were significantly decreased(P
