Effects of H_2O_2 and 11,12-EET in EDHF mediated relaxation in the rat basilar arteries
- VernacularTitle:过氧化氢和11,12-环氧二十碳三烯酸对内皮依赖性超极化因子介导的脑基底动脉舒张作用的影响
- Author:
Biao SONG
;
Zhiwu CHEN
;
Yifei FAN
- Publication Type:Journal Article
- Keywords:
Endothelium-dependent hyperpolarizing factor;
Vascular relaxation;
Hydrogen peroxide;
Catalase;
11,12-epoxyeicosatrienoic acid
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the effects of Hydrogen Peroxide(H2O2)and 11,12-epoxyeicosatrienoic acid(11,12-EET)on EDHF-mediated relaxation in the rat basilar arteries.METHODS: The relaxant effects of acetylcholine(ACh),H2O2,11,12-EET,and catalase(CAT) on rat arteria basilaris in vitro were detected by vasomotoricity experiment in vitro.RESULTS: In the rat basilar arteries,preconstricted by 30 mmol/L KCl in vitro,ACh(10-7-10-4.5 mol/L) had the concentration-dependent relaxation effect.3?10-5 mol/L N?-nitro-L-arginine-methyl-ester(L-NAME) and 10-5 mol/L indomethacin(Indo) could partly inhibit the relaxation effect of ACh to the rat basilar arteries,but non-No/non-PGI2-mediated relaxation was still significant(P
