Gaseous signal molecule hydrogen sulfide and penile erection
- VernacularTitle:内源性硫化氢与阴茎勃起
- Author:
Hua LUO
;
Aiping FENG
;
Mingquan QIU
- Publication Type:Journal Article
- Keywords:
hydrogen sulfide;
cystathionine-beta-synthase;
cystathionine-?-lyase;
penile erectile;
erectile dysfunction
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Endogenous hydrogen sulfide is the third gaseous signal molecule after nitric oxide and carbon monoxide;it is synthesized through cystathionine-?-synthase and cystathionine-?-cleavage pathway.Hydrogen sulfide can directly react with the KATP channel,reduce extracellular Ca2+ influx,and work together with testosterone,nitric oxide,carbon monoxide,relaxing corpus cavernosum smooth muscle and improving diastolic function of blood vessels.It can also inhibit vascular smooth muscle cell proliferation,promote apoptosis,and improve vascular remodeling.Therefore,in-depth study of H2S in the regulating penile erection can provide a new way for the treatment of erectile dysfunction.
