Evodiamine-stimulated dentritic cells of spinal cord homogenate protein promotes repair of spinal cord injury in mice
- VernacularTitle:吴茱萸碱刺激的负载脊髓匀浆蛋白DCs促进小鼠脊髓损伤的修复
- Author:
Ke WANG
;
Jianhua ZHAO
;
Huaping LIANG
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
dendritic cell;
evodiamine;
homogenate protein of spinal cord
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of evodiamine(EVO)-stimulated dendritic cells(DC) of spinal cord homogenate protein(hpDC) on repair of spinal cord injury(SCI) in mice.Methods Twenty hours after SCI,mice were randomly divided into 6 groups and injected with PBS,EVO,DC,DC+EVO,hpDC and hpDC+EVO.BMS and histopathology were used to observe the effect of hpDC+EVO on the functional recovery of spinal cord injury and pathological changes such as local scars.Levels of brain-derived neurotrophic factor(BDNF),neurotrophin-3(NT-3),interleukin-12(IL-12) and granulocyte macrophage colony stimulating factor(GM-CSF) in injured sites and supernatant of cultured T cells were measured by ELISA.Results Eighty-four days after treatment,the BMS was significantly higher in hpDC + EVO group than in other groups(P
