Effects of Borneol on the Pharmackinetics of Scutellarin after Intranasal Administration in Rats
- VernacularTitle:冰片对灯盏花素鼻腔给药在大鼠体内药动学的影响
- Author:
Senlin SHI
;
Jingjing WU
;
Weihong GE
- Publication Type:Journal Article
- Keywords:
scutellarin;
intranasal administration;
borneol;
pharmacokinetics
- From:
Journal of Zhejiang Chinese Medical University
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To observe the effects of borneol on the pharmackinetics of scutellarin after intranasal administration in rats.[Method]The different time of plasma scutellarin concentration was determined by the method of 125I label after iv injection or intranasal administration,intranasal administration of scutellarin(combined with 1% borneol)0.4 mg?kg-1 in SD rats.To calculate the pharmacokinetic parameters by 3P87 software.[Result]The time of maximum concentration(Tmax)and the maximum concentration(Cmax)at the class of intranasal administration is 25.0 min,0.55ug/ml,at the class of intranasal administration(combined with borneol)46.5 min,0.50ug/ml;the absolute bioavailability of intranasal administration is 53.70%,while the intranasal administration(combined withborneol)is 52.86%,there is no statistically significant differences compared with each other.[Conclusion]The borneol prolongs the peak time of plasma scutellarin concentration after intranasal administration in rats,but AUC is not influenced.
