Study on Influence of EPO on Rabbits' TNF-?,IL-6,IL-10 and MDA with Blood Loss Shock and Endotoxemia
- VernacularTitle:EPO对失血性休克合并内毒素血症兔TNF-?、IL-6、IL-10、MDA影响的研究
- Author:
Liang XU
- Publication Type:Journal Article
- Keywords:
endotoxemia;
EPO;
dysfunctional multi-organs;
cytokines
- From:
Journal of Zhejiang Chinese Medical University
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore the rabbits' lipid peroxidation and cytokine level change caused by endotoxemia,use EPO for intervention.[Method]Bleed rabbits femoral for shock,after coming to,make injection of endotoxin,two beatings make dysfunctional multi-organs model;randomly divide 24 healthy rabbits into control group(1),2-beating group(2),EPO group(3),8 in each;take blood for testing indexes of TNF?,IL6,IL10 and MDA.[Result]Group 2 was higher than other groups on MDA level,group 3 less than group 2;group 2 was much higher than other 2 groups on TNF?,IL6 and IL10,group 3 less than group 2.[Conclusion]The cytokines and lipid peroxidation participating in the course of multi-organ injury caused by blood loss shock and endotoxemia can be reduced by EPO.
