Study of the Expression and Significance of P53 and nm23 in Colorectal Adenocarcinom.
- VernacularTitle:结直肠癌中P53、nm23的表达研究及临床意义
- Author:
Feng SONG
;
Feng GAO
;
Liang DONG
;
Xin ZHANG
;
Yong ZHAO
- Publication Type:Journal Article
- Keywords:
Colorectal adenocarcinoma;
P53;
nm23;
Immunohistochemistry;
Expression
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and significance of P53 and nm23 in colorectal adenocarcinoma.Methods The expression of P53 and nm23 was examined by immunohistochemical technique in 83 cases of colorectal adenocarcinoma.Results In colorectal adenocarcinoma,the positive intensities of P53 and nm23 was associated with tumour depth,histological grade,lymph node metastasis diseases and distant metastasis disease(P0.05).Conclusion P53 and nm23 may play an important role in the development and metastasis of colorectal adenocarcinoma.It is an useful marker for predictinng the prognosis of colorectal adenocarcinoma.
