Establishment of Age- and Gender-Specific Reference Ranges for 36 Routine and 57 Cell Population Data Items in a New Automated Blood Cell Analyzer, Sysmex XN-2000.
10.3343/alm.2016.36.3.244
- Author:
Sang Hyuk PARK
1
;
Chan Jeoung PARK
;
Bo Ra LEE
;
Mi Jeong KIM
;
Min Young HAN
;
Young Uk CHO
;
Seongsoo JANG
Author Information
1. Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. cjpark@amc.seoul.kr
- Publication Type:Brief Communication ; Evaluation Studies
- Keywords:
Age;
Automated blood cell analyzer;
Gender;
Item;
Reference range;
Sysmex XN-2000
- MeSH:
Adult;
Age Factors;
Aged;
Automation;
Blood Cell Count/*methods/standards;
Female;
Humans;
Male;
Middle Aged;
Reference Values;
Sex Factors
- From:Annals of Laboratory Medicine
2016;36(3):244-249
- CountryRepublic of Korea
- Language:English
-
Abstract:
We established age- and gender-specific reference ranges for the 36 routine complete blood cell (CBC) and 57 cell population data (CPD) items in the Sysmex XN-2000 (Sysmex, Japan). In total, 280 peripheral blood samples were obtained from an equal number of healthy adults. Values for 36 routine items and 57 CPD items were obtained for each sample, and the results were categorized into six subgroups (N>39 in each subgroup) according to patient age (20-40, 41-60, and >60 yr) and gender (male and female), and compared with respect to age and gender differences. The majority of data items (22 of 36 routine CBC items and 44 of 57 CPD items) exhibited significant differences (P< or =0.05) in their results with respect to age or gender, and several red cell-, lymphocyte-, and platelet-related data tended to decrease in women or older adults. These results provide a basis for establishing age- and gender-specific reference ranges for routine and CPD items in Sysmex XN-2000. Furthermore, these reference ranges could be used to determine clinical significance for new items of Sysmex XN-2000 in further studies.
