Mechanism and effect of Tangzu Heji on diabetic foot rat with blood stasis syndrome
- VernacularTitle:糖足合剂对瘀血阻滞证糖尿病足大鼠的治疗作用及机制
- Author:
Maocan TAO
;
Ping HUANG
;
Jinglun XU
;
Juanjuan GAO
;
Yi CAO
- Publication Type:Journal Article
- Keywords:
Diabetic foot;
Chinese drug therapy;
Blood stasis syndrome;
VEGF;
Rats.
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect on Tangzu Heji on diabetic foot rat with blood stasis syndrome and to investigate the mechanism in it. Methods: Combination of streptozocin injection and reduction of ambient temperature was used to duplicate diabetic foot rat with blood stasis syndrome. 60 Male SD rats were randomly divided into 6 groups as normal control group, the low temperature control group, diabetic foot group (model group), three groups of Tangzu Heji treatment with high, medium and low dose respectively. In the first three groups the rats were given normal saline, and in the latter three treatment groups the model rats were given Tangzu Heji as 60gkg, 30g/kg, 15g/kg weight, respectively. After two weeks of treatment, the changes of the weight, water intake, blood glucose, blood rheology, acral gangrene symptoms, Choroid blood vessels of the sublingual and ear, serum vascular endothelial growth factor changes were observed. Results: After two weeks of treatment with Tangzu Heji, compared with the model group, a marked increase in body weight, decrease of water intake were happened to the rats in treatment groups. Erythrocyte aggregation index in the low-dose treatment group decreased significantly (P
