Influence of BushenHuoxuefang on the Expression of Platelet Derived Growth Factor BB in Renal Interstitial Fibrosis Rats
- VernacularTitle:补肾活血方对肾间质纤维化大鼠肾组织中血小板衍生生长因子蛋白表达的影响
- Author:
Zhiqing GAO
;
Haopeng KANG
;
Jun ZHANG
;
Linqi ZHANG
- Publication Type:Journal Article
- Keywords:
BushenHuoxueFang;
Renal tubulointerstitial fibrosis;
Unilateralureteral obstruction rat;
Platelet derived growth factor BB
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the protective effect of BushenHuoxueFang on renal interstitial fibrosis in rats and try to explore the mechanism. Methods: The renal obstruction model of rats was established by unilateralureteral obstruction ,and then they were divided into four groups randomly, including sham-opration group,model group,Lotensin group, BushenHuoxueFang high-dose and low dose group.The morphological changes of kidney tissue were observed,the level of PDGF-BB was detected by Western-blot on the third,seventh,fourteenth and twenty first,twenty eighth day Results: Compared with the sham-operation group, there were different degrees of kidney lesions in UUO group and the treatment groups. The level of PDGF-BB in UUO group was significantly higher than that in sham-operation group from the third day(P
