Association of serum proinsulin with insulin resistance,and serum proamylin with islet beta cell function
- VernacularTitle:胰岛素原和胰淀素原水平与胰岛素抵抗和胰岛?细胞功能的相关性研究
- Author:
Xiaoya ZHENG
;
Wei REN
;
Suhua ZHANG
;
Ping YANG
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
proinsulin;
proamylin;
amylin;
insulin resistance
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the serum levels of proinsulin(PI),insulin(INS),proamylin(PA) and amylin(AMY) in abnormal glucose metabolism individuals and to explore the relationship between PI and insulin resistance(IR) and between PA and islet beta cell function.Methods Totally 79 subjects who received Oral glucose tolerance test(OGTT) and insulin release test in our department from March to May 2008 were divided into 4 groups according to the results of OGTT,that is,normal group,impaired glucose regulation(IGR) group,T2DM 1[fasting blood-glucose(FBG)15 mmol/L) group.All subjects underwent examination of anthropometry and serum bio-chemical indicators,HOMA-IR and HOMA-B were calculated.Results No significant difference was found in the serum levels of PI or AMY among the 4 groups,but the level of PA,PI/INS and PA/AMY among the 4 groups did have significant differences(P
