Clinical study of protective effects and function regulations of piperazine ferulate tablet on traumatic vascular endothelial cells in type 2 diabetes mellitus
- VernacularTitle:阿魏酸哌嗪对2型糖尿病血管内皮细胞的保护及功能调节的临床研究
- Author:
Yan JIN
;
Hui QIU
;
Xiaochun LAN
;
Xiaojing HUO
- Publication Type:Journal Article
- Keywords:
Piperazine ferulate;
Type 2 diabetes mellitus;
Endothelial cell
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the therapeutic protective effects and function regulations of conventional antidiabetic treatment plus piperazine ferulate tablet on traumatic vascular endothelial cells in type 2 diabetes mellitus.METHODS:80 patients were randomly divided into the treating group(n=37)and the control group(n=43).Conventional antidiabetic treatment plus piperazine ferulate was given to the treating group,and the control group was treated with conventional antidiabetic treatment plus vitamin C every day,and all the patients were treated with 4 weeks.The levels of fasting blood glucose(FBG),glycosylated hemoglobin A1C(Hb A1C),circulating endothelial cell(CEC),serum lipid peroxide(LPO),endothelin(ET)、nitric oxide(NO),tissue-plasminogen activator(t-PA)were determined during the therapeutic period.RESULTS:After 4 weeks of treatment,the levels of serum CEC,LPO and ET were lower in the treating group than those in the control group(P
