Regulating effect of Tongxinluo on HIF-1?,VEGF generated by the human brain microvascular endothelial cells induced by ?-amyloid1-42
- VernacularTitle:通心络对A?_(1-42)损伤人脑微血管内皮细胞HIF-1?、VEGF表达的干预作用
- Author:
Zhihui ZHANG
;
Yiling WU
- Publication Type:Journal Article
- Keywords:
human brain microvascular endothelial cells;
Amyloid ? protein;
VEGF;
HIF-1?;
Tongxinluo
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the regulating effect of Tongxinluo on HIF-1?,VEGF that Generated by the Human brain microvascular endothelial cells induced by ?-amyloid 1-42. Methods Human brain microvascular endothelial cells were pre-incubated for 4h by Tongxinluo,then injured by ?-amyloid 1-42. VEGF protein and HIF-1? were detected by Western blot. Result In the A? treated Human brain microvascular endothelial cells,viable cells decreased. The expression of VEGF was Reduced,and HIF-1? elevated. After the cells were treated with Tongxinluo,all the above indexes were improved. Conclusion Tongxinluo can enhance the VEGF protein expressions by the HIF-1? and protect the Human brain microvascular endothelial cells.
