Association Between Angiotension-converting Enzyme and Stroke
- VernacularTitle:血管紧张素转移酶基因多态性与脑卒中的关系
- Author:
Feng LI
;
Huidong DOU
;
Zhansen XIAO
;
Runtian ZHAO
;
Kuo CHEN
;
Xiaoming TAO
;
Yujing SUN
;
Shuqin HOU
;
Changchun QIU
- Publication Type:Journal Article
- Keywords:
Cerebral hemorrhage;
Cerebral infarction;
ACE;
Gene;
Polymorphism
- From:
Journal of Medical Research
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between ACE gene polymorphisms and stroke of Han nationality people in Fangshan district of Beijing. Methods The Insertion/Deletion(ID) polymorphisms of ACE gene were detected in 63 patients with cerebral hemorrhage,and 713 patients with cerebral infarction and 235 health control by polymerase chain reaction(PCR). We observed the frequencies of genotype of deletion homozygote(DD),insertion homozygote(II) and insertion/deletion heterozygote (ID) and the alleles of D and I. Also we analyzed the association among I/D polymorphisms of ACE gene with serum glucose(GLU),triglyceride(TG),cholesterol(TC) levels. Results There was no significant difference in the frequencies of both genotypes of DD,ID,II and alleles of D and I in three groups. The serum GLU levels in patients carrying ID,II genotype were higher than those in healthy control(P
